Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials

BB Yeap; ST Page; M Grossmann

Journal article

Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials

BB Yeap, ST Page, M Grossmann

Lancet Diabetes and Endocrinology | ELSEVIER SCIENCE INC | Published : 2018

DOI: 10.1016/S2213-8587(17)30416-3

Abstract

A decrease in the concentration of circulating testosterone in many older men is a biomarker and possibly a rectifiable contributing factor to ill health. Low circulating testosterone concentration has been associated with cardiovascular disease, reduced cognition, fracture risk, and anaemia. However, randomised placebo-controlled trials are essential to clarify the benefits and possible risks of testosterone treatment in men without hypothalamic, pituitary, or testicular disease. The Testosterone Trials (T-Trials) were a coordinated set of trials that, following a screening-to-enrolment ratio of 65:1, randomly assigned 790 men aged 65 years or older who had a baseline testosterone concentra..

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University of Melbourne Researchers

Mathis Grossmann Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

BBY is a recipient of National Health and Medical Research Council of Australia Project Grants (1030123, 1045710, 1060557, 1121548, and 1128083). STP is supported by the Robert B McMillen Professorship in lipid research and by the Eunice Kennedy Shriver National Institute of Child Health and Development Contraceptive Clinical Trials Network (HHSN275201300025I). MG is supported by National Health and Medical Research Council of Australia Project Grants (1099173, 1062073, and 1030123).